期刊简介
主要报道和刊登国内外、特别是我国消化病学者具有创造性的、有较高学术水平的基础和临床研究论文、研究快报等. 对具有中国特色的研究论文, 如食管癌、胃癌、肝癌、大肠癌、病毒性肝炎、幽门螺杆菌、中医中药、中西医结合和基于作者自己研究工作为主的综述性论文, 将优先发表. 读者对象为基础研究或临床研究的消化专业工作者。
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首页>世界华人消化杂志
- 杂志名称：世界华人消化杂志
- 主管单位：华人消化杂志；新消化病学杂志
- 主办单位：山西省科学技术厅
- 国际刊号：14-1260/R
- 国内刊号：14-1260/R
- 出版周期：旬刊
期刊荣誉：国家期刊奖百种重点期刊（第二和第三届）期刊收录：上海图书馆馆藏, 国家图书馆馆藏, 文摘与引文数据库, 维普收录(中), 医学文摘, 知网收录(中), CA 化学文摘(美), 万方收录(中)
GSTM1和T1基因多态性与AFT暴露和肝癌
董传辉；俞顺章；陈公超；赵德明；符艳
关键词：liver neoplasms, aflatoxin, glutathion S-transferase, polymorphisms, enzyme linked immunosorbent assay, genotypes, Polymerase Chain Reaction, risk factors
摘要：AIM To explore the relationship between the level of aflatoxin-human serum albumin adducts and polymorphisms of glutathione S-transferase (GST) M1 and T1 and primary liver cancer (PLC).METHODS AFT-albumin adducts were measured by sandwich enzyme-linked immunosorbent assay (ELISA) and genotypes of GST M1 and T1 were determined by PCR.RESULTS Compared with those with non-null genotype of both GST T1 and M1, the odds ratio of developing PLC for those with null genotype of both GST T1 and M1 was 3.11 (95% confidence interval: 1.01-9.98; P=0.029). There was a dose-response relationship between serum level of AFT-albumin adducts and risk of PLC (χ2trend=15.42, P=0.0001). By combined genotype of GST T1 and M1, persons with null genotype of GST T1 and M1 were more likely to have higher AFT-albumin adduct level than those with other genotypes of GST T1 and M1 (F=4.57, P＜0.005). The biological gradients between serum AFT-albumin adducts level and PLC risk were observed to determine whether the persons were of null genotype of GST T1 or M1 or not. The levels of AFT-albumin adduct in Haimen residents in 1992 and 1996 were decreased significantly as against 1987 (F=6.35, P＜0.005).CONCLUSION Exposure to aflatoxin may still be one of risk factors leading to PLC endemic in Haimen population and those with null genotype of GST T1 and M1 may be at greater risk of developing PLC once they are exposed to aflatoxin.
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